Abstract
Abstract Adrenal steroid changes were measured serially in groups of volunteers throughout the course of experimental infection with Pasteurella tularensis. To relate altered adrenal function to different patterns of clinical response, corticosteroids of volunteers were studied following exposure to airborne organisms: a) for the first time, b) after prior vaccination, and c) after recovery from typhoidal tularemia. The urinary excretion of corticosteroids was increased during typical acute illness. With the onset of symptoms, 17-hydroxycorticosteroid (17-OHCS) excretion increased progressively to approximately double the control values. Within one day after initiation of streptomycin therapy and prior to the disappearance of fever and symptoms, urinary 17-OHCS excretion became normal; streptomycin administered similarly to nonexposed control subjects produced no detectable change in adrenocortical hormone excretion. Increases in 17-ketosteroids (17-KS) and pregnanetriol excretion during illness were less...
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