Abstract
ABSTRACT The concentrations of free and conjugated 17-OHCS in the plasma, the excretion of 17-OHCS into the urine, and the 17-OHCS clearance were determined in control subjects and renal patients after an intravenous injection of cortisol. The average content of conjugated 17-OHCS in the plasma before the injection was three times higher in the renal group than in the control group. The conjugated 17-OHCS clearance after cortisol injection in the renal patients was three times lower than in the control group. As the clearance investigation does not offer any advantages compared with the determination of conjugated 17-OHCS in the plasma, the authors consider that, because of its simplicity the last-mentioned determination is as the best clinical test for measuring the steroid status in renal patients.
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