Abstract
In parotid slices and membranes from Wistar rats 2, 12 and 24 months old, changes are noted in adrenoceptor-stimulated K + fluxes, formation of [ 3H]inositol phosphates ([ 3H]IPs), cAMP production, and membrane environment. Norepinephrine-stimulated K + efflux and formation of [ 3H]IPs in the slices proceed through an α 1-adrenergic mechanism and are reduced 20% and 40% during aging, respectively. In β-adrenoceptor stimulation with isoproterenol, no age changes were observed in K + influx and cAMP production. The cholesterol content in membranes was reduced with age; concomitantly, the membrane viscosity decreased with age. These results indicate that the alterations in the membrane environment may provide age-dependent modulation of α 1-adrenoceptor coupling mechanisms and their functions.
Published Version
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