Abstract
Pineal hydroxyindole-O-methyltransferase (HIOMT) activity is known to decline slowly in rats exposed to constant light. We have found that long-term, in vivo isoproterenol treatment prevents and reverses this decline. Similarly, enzyme activity declines slowly in rats after bilateral superior cervical ganglionectomy. We have also found this effect can be prevented by long-term, in vivo treatment with norepinephrine or isoproterenol. These results, the first demonstration that HIOMT activity can be stimulated by treatment with adrenergic agonists, indicate that the neurotransmitter involved in the adrenergic control of HIOMT activity is norepinephrine.
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