Abstract
The effects of prepuberal hypophysectomy and ovariectomy on hydroxyindole- O-methyltransferase (HIOMT) activity were investigated in the female rat. Hypophysectomy performed at 28 days was found to result in lower pineal wt and HIOMT activity at 53 days of age. Ovariectomy performed at 28 days did not significantly affect pineal wt but resulted in increased HIOMT activity at 53 days of age. Injection of 50 μg estradiol benzoate at 50 and 52 days of age reversed the effect of ovariectomy on HIOMT activity at 53 days of age. These results suggest that HIOMT activity in the prepuberal rat is stimulated in some unknown manner by the pituitary and inhibited by the ovary, possibly by estrogen. (Endocrinology 86: 1166, 1970)
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