Abstract
Our current understanding of neonatal adrenal function is incomplete. Relationship between basal cortisol levels and various neonatal outcomes are inconclusive. However, direct precursor-to-product ratio can provide useful information about the network of pathways in cortisol biosynthesis. Objective: For this reason, we conducted a prospective study to assess adrenal steroid profile at birth. We studied the levels of 7 precursors and products of adrenal steroids in the cortisol biosynthesis / degradation pathway using liquid chromatography-tandem mass spectrometry …
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