Abstract
The effect of the oral contraceptive Norinyl (1 or 2 mg norethindrone 100 mcg mestranol) on the hypothalamic-pituitary-adrenal response to Piromen (Pseudomonas polysaccharide complex) methopyrapone and exogenous ACTH was investigated in 8 subjects. Norinyl use significantly (p less than .001) lowered both urinary excretion of 17-ketogenic steroids (KGS) and 17-ketosteroids. The response to methopyrapone was markedly impaired during Norinyl treatment though the hypophyseal-adrenal response to Piromen was normal. The results indicate that Norinyl and presumably other progestational agents do not affect the pituitary-adrenal response to stress even though the response to methopyrapone was impaired.
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