Adrenal cortical function and the pathogenesis of rheumatoid arthritis.

Abstract

Editorial1 September 1956ADRENAL CORTICAL FUNCTION AND THE PATHOGENESIS OF RHEUMATOID ARTHRITISHOWARD L. HOLLEY, M.D.HOWARD L. HOLLEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-45-3-550 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor a long time clinical investigators have postulated that the etiology of rheumatoid arthritis might have metabolic implications. At one time the parathyroid glands were considered to have an important relationship to the disease, and it was believed that parathyroid dysfunction caused the changes in the bones and joints. Hyperthyroidism and hypothyroidism have likewise been considered to have an etiologic linkage in the pathogenesis of this disease. Careful studies, however, have failed to reveal a relationship of any of these endocrinologic disorders to rheumatoid arthritis.On the other hand, there are certain clinical characteristics of the disease, i.e., profound muscle...1 HenchKendallSlocumbPolley PSECCHHF: Effect of hormone of adrenal cortex (17-hydroxy-11-dehydrocorticosterone: Compound E) and of pituitary adrenal corticotropic hormone on rheumatoid arthritis; preliminary report, Proc. Staff Meet., Mayo Clinic 24: 181-187 (April 13) 1949. MedlineGoogle Scholar2 PereraRagan GAC: Hypoadrenalism: Steroidal mediation of sodium action on blood pressure; modification of antiarthritic response to cortisone, Proc. Soc. Exper. Biol. and Med. 75: 99-103 (October) 1950. CrossrefMedlineGoogle Scholar3 SokoloffSharpKaufman LJTEH: The adrenal cortex in rheumatic disease; pathologic study with special reference to effects of cortisone and corticotropin, A.M.A. Arch. Int. Med. 88: 627-639 (Nov.) 1951. CrossrefGoogle Scholar4 DavisonKoetsKuzell RAPWC: Excretion of 17-ketosteroids in ankylosing spondylarthritis and in rheumatoid arthritis; preliminary report, J. Clin. Endocrinol. 7: 201 (Mar.) 1947. CrossrefGoogle Scholar5 Desmarais MH: The neutral 17-ketosteroids in rheumatoid arthritis and spondylitis, Ann. Rheumat. Dis. 8: 296 (Dec.) 1949. CrossrefMedlineGoogle Scholar6 HenchKendallSlocumbPolley PSECCHHF: Effects of cortisone acetate and pituitary ACTH on rheumatoid arthritis, rheumatic fever and certain other conditions; a study in clinical physiology, Arch. Int. Med. 85: 545 (Apr.) 1950. CrossrefGoogle Scholar7 FreundBazinskiScott HADHRB: 17-ketosteroid excretion in rheumatoid arthritis, J. Michigan M. Soc. 49: 1076 (Sept.) 1950. MedlineGoogle Scholar8 HowardVenningFisk RPEHGH: Rheumatoid arthritis; studies of adrenocortical and hypophyseal function and the effects thereon of testosterone and pregnenolone therapy, Canad. M.A.J. 63: 340, 1950. MedlineGoogle Scholar9 StaubMentheNelsonCohn PLJWSSH: Excretion of 11-oxycorticosteroids in paraplegic and rheumatoid arthritis patients, J. Clin. Investigation 29: 349 (Mar.) 1950. CrossrefMedlineGoogle Scholar10 Robinson WD: Discussion of footnote 17, Ann. Rheumat. Dis 15: 71 (Mar.) 1956. Google Scholar11 Kelly VC: Rationale for hormone therapy in rheumatic fever, Ann. N. York Acad. Sc. 61: 369-376 (May 27) 1955. CrossrefMedlineGoogle Scholar12 PetersonWyngaordenGuerraBrodieBunim REJBSLBBJJ: The physiological disposition and metabolic fate of hydrocortisone in man, J. Clin. Investigation 37: 779-794, 1955. Google Scholar13 Hill SR: Unpublished data. Google Scholar14 Fisher FK: Corticotropin and cortisone in rheumatoid arthritis, Acta med. Scandinav. Suppl. 305: 137, 1955. Google Scholar15 Dobriner K: Symposium on steroids in experimental and clinical medicine, 1951, The Blakiston Company, Philadelphia, p. 130. Google Scholar16 Holley HL: Recent advances in steroid therapy of rheumatoid arthritis, Mississippi Doctor 33: 257-259 (Feb.) 1956. MedlineGoogle Scholar17 HillHolleyStarnesHibbett SRHLWRLL: Studies on the diurnal pattern of urinary 17-hydroxycorticoid and 17-ketosteroid excretion in patients with rheumatoid arthritis, Ann. Rheumat. Dis. 15: 69-71 (March) 1956. Google Scholar18 ThornLaidlaw GWJC: Studies on the adrenal cortical response to stress in man, Tr. Am. Clin. and Climat. A. 65: 179, 1954. Google Scholar19 Warren JE: Discussion of footnote 17, Ann. Rheumat. Dis. 15: 70 (March) 1956. Google Scholar20 Wilson H: Discussion of footnote 17, Ann. Rheumat. Dis. 15: 70 (March) 1956. Google Scholar21 Sheehan HL: Simmonds' disease due to postpartum necrosis of the anterior pituitary, Quart. J. Med. 8: 277-309 (Oct.) 1939. Google Scholar22 Pearse AG: The hypophysis in rheumatoid arthritis, Lancet 1: 954 (May 20), 1950. CrossrefMedlineGoogle Scholar23 Peterson RE: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByStudies on adrenal cortical activity in patients with rheumatoid arthritis: The diurnal pattern and twenty-four hour levels of urinary total 17-hydroxycorticosteroids and 17-ketosteroidsAddison's Disease and Rheumatoid Arthritis 1 September 1956Volume 45, Issue 3Page: 550-555KeywordsBoneEtiologyHyperthyroidismHypothyroidismMusclesParathyroidPathogenesisRheumatoid arthritis Issue Published: 1 September 1956 PDF DownloadLoading ...