Abstract
The PAT family of proteins has been identified in eukaryotic species as diverse as vertebrates, insects, and amebazoa. These proteins share a highly conserved sequence organization and avidity for the surfaces of intracellular, neutral lipid storage droplets. The current nomenclature of the various members lacks consistency and precision, deriving more from historic context than from recognition of evolutionary relationship and shared function. In consultation with the Mouse Genomic Nomenclature Committee, the Human Genome Organization Genomic Nomenclature Committee, and conferees at the 2007 FASEB Conference on Lipid Droplets: Metabolic Consequences of the Storage of Neutral Lipids, we have established a unifying nomenclature for the gene and protein family members. Each gene member will incorporate the root term PERILIPIN (PLIN), the founding gene of the PAT family, with the different genes/proteins numbered sequentially.
Highlights
The PAT family of proteins has been identified in eukaryotic species as diverse as vertebrates, insects, and amebazoa
PAT derives from names of three proteins, PERILIPIN, ADRP, and TIP47, with each having highly related
Perilipin mRNA and protein expression is largely restricted to adipocytes [5] and steroidogenic cells [6], when ectopically expressed, it is exclusively found on LSDs, regardless of cell type [7,8,9]
Summary
The murine Plin gene organization is the most fully characterized of the Plin gene family [1]. Closely situated alternative 5′transcriptional start sites have been described. The mRNA splice variants are predicted to encode four distinct proteins, previously termed perilipin A, B, C, and D; three of these proteins have been confirmed [5, 6]. Lower case letters will denote alternative protein forms PLIN1a, PLIN1b, PLIN1c, and PLIN1d, with Plin1a, Plin1b, Plin1c, and Plin1d as their respective mRNAs. Alternative 5′-starts would be noted as the mRNA variants Plin1a_v1, Plin1a_v2, etc. Similar nomenclature will follow for the other members
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