Abstract
Objectives:To explore the significance of the hemodynamic parameters of Computerized Tomography Perfusion Imaging (CTPI) under the deconvolution optimization algorithm for the diagnosis and treatment of patients with acute cerebral infarct (ACI).Methods:A hundred and ten patients with ACI from December 2018 to September 2019 were selected for research, and CTPI was performed before and after Edaravone injection treatment. Then, the CTPI deconvolution algorithm based on the weighted adaptive (WA) total variation (TV) (WA-TV) optimization was constructed, which was compared with tensor total variation (TTV) and Motion-adaptive sparse parity (MASP). Brain Perfusion 4.0 was applied to obtain the relative time to peak (rTTP), the relative transit time of mean (rMTT), relative cerebral blood volume (rCBV), and relative cerebral blood flow (rCBF) of the core infarction area (CIA) and penumbra ischemic (PI).Results:In four parameters of rTTP, rMTT, rCBV, and CBF, the peak signal to noise ratio (PSNR) of the WA-TV algorithm was higher than the MSAP and TTV algorithms, while the Mean Square Error (MSE) and Mean Absolute Error (MAE) were lower than MSAP and TTV algorithms (P<0.05); the parameters of rCBV (71.56±9.87), rCBF (43.17±7.06) of the CIA before treatment were higher than PI (23.66±7.22; 18.37±3.99), rMTT (124.83±9.73) and rTTP (122.57±7.41) were lower than the PI (183.17±10.16); 150.74±9.74) (P<0.05). After treatment, the rCBV and rCBF of PI were higher than before treatment, and rMTT and rTTP were lower than before treatment (P<0.05), and there was no obvious difference in rCBV, rCBF, rMTT, and rTTP before and after treatment in the CIA (P>0.05).Conclusion:Compared with TTV and MASP, the WA-TV algorithm performs better in noise reduction and artifact reduction. The CTPI parameters of rCBV, rCBF, rMTT, and rTTP are all important indications for the diagnosis of PI and ACI.
Highlights
ACI may occur if abnormal objects enter the cerebral arteries or the neck arteries, block blood flow, and soften or even necrotize the brain tissues.[1,2] The current clinical treatments for ACI include general treatment, thrombolytic therapy, and drug therapy
The results showed that the WA-TV algorithm proposed in this study had a higher PSNR in contrast to the TTV and MASP algorithms after the CTPI images were processed
The larger the PSNR value, the closer the resolution of the reconstructed image to the original image.[11,12,13]. It suggested that the resolution of the CTPI image reconstructed by the WA-TV algorithm proposed in this study was higher, and the reconstruction result was significantly better than that of the TTV and MASP algorithms
Summary
ACI may occur if abnormal objects (solid, liquid, gas) enter the cerebral arteries or the neck arteries, block blood flow, and soften or even necrotize the brain tissues.[1,2] The current clinical treatments for ACI include general treatment, thrombolytic therapy, and drug therapy. Pak J Med Sci September 2021 (Speical Issue Online) Vol 37 No 6 www.pjms.org.pk 1687 recombinant tissue-type plasminogen activator to treat patients with intravenous thrombolysis. Medications include mannitol, heparin, and Edaravone.[3,4,5] CT can check the lesions of patients with ACI, with low cost, fast examination, and non-invasiveness. CTPI can check the brain with contrast agent injection,[4,5,6,7] providing help for the clinical development of personalized thrombolytic therapy. Deconvolution can calculate various myocardial perfusion hemodynamic parameters, including myocardial blood flow and myocardial blood volume, to assess myocardial ischemia.[8,9,10]
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