Abstract
Nystatin, one of the polyenic antifungal antibiotics which are known to interact primarily with sterols in the cell membrane, was found to exert adjuvanticity on the primary in vitro antibody response of mouse spleen cells to heterologous erythrocyte antigens, possibly by affecting the events in early inductive phase of the response. The adjuvanticity of nystatin was also shown in a synergistic fashion on the antibody response of the cultures which was enhanced with 2-mercaptoethanol (2-ME), and addition of nystatin and 2-ME to the cultures augmented their antibody response far greater than that in the cultures added with either one of the adjuvants alone. Among the polyenic antibiotics, amphotericin B, which has amphoteric characteristics similar to nystatin, also exerted adjuvanticity on the antibody response, while nonamphoteric filipin suppressed the antibody response. Though the mode of action of nystatin on the antibody response has not been clarified at present, nystatin may provide a useful clue for analysis at molecular level of cellular events associated with the induction of antibody response because of the proposed action of the drug on the cell membrane.
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