Adiponectin rs2241766 and rs266729 gene polymorphisms in non-alcoholic fatty liver disease

Abstract

BackgroundIn this study, we aimed to examine the association of adiponectin (ADIPOQ) rs2241766 (+45T/G) and rs266729 (−11377C/G) gene polymorphisms with serum ADIPOQ in non-alcoholic fatty liver disease (NAFLD). MethodsADIPOQ rs2241766 and rs266729gene polymorphisms were genotyped by using TaqMan 5′-nuclease assay and serum ADIPOQ level was measured in 100 NAFLD patients and 100 healthy controls. ResultsThe study revealed an association of G- allele of ADIPOQ rs2241766 gene polymorphism with NAFLD; X2 (P-value); 3.95 (0.047). Moreover, G-allele of ADIPOQ rs266729 gene polymorphism increased significantly in the patients compared to controls, X2 (P-value): 3.9 (0.046). The study also revealed lower serum ADIPOQ levels in NAFLD patients compared to controls (P < 0.001). There was no association between ADIPOQ rs266729 and rs2241766 gene variants and serum ADIPOQ levels in the participants. In NAFLD patients, Low serum ADIPOQ was associated with elevated liver enzymes and altered lipid profile values. ConclusionG-alleles of rs2241766 (+45 T/G) and rs266729 (−11377C/G) gene polymorphisms of ADIPOQ gene were associated with NAFLD, but not with serum ADIPOQ levels.