Abstract
Our aim was to investigate if single nucleotide polymorphisms (SNPs) located in the 5′ regions of leptin (LEP, -2548 G > A, rs7799039), resistin (RETN, -420 C > G, rs1862513) and adiponectin (ADIPOQ, -11391 G > A, rs17300539 and -11377 C > G, rs266729) genes were related to changes in body mass index (BMI) and metabolic variables after bariatric surgery in 60 extremely obese individuals. At baseline, ADIPOQ -11391 A-allele carriers showed higher plasma adiponectin and lower total cholesterol levels when compared to G/G homozygotes. Approximately 32 months post-surgery, a mean reduction of 35% in BMI and an important improvement in metabolic profiles were observed. In addition, for the ADIPOQ -11377 polymorphism, a higher decrease in lipid profile was associated to the C/C genotype. Moreover, individuals bearing the A-C haplotype for the two ADIPOQ SNPs were more prone to show a reduction in low-density lipoprotein levels after bariatric surgery (-43.0% A-C carriers vs. -18.1% G-G carriers, p = 0.019). We did not find any association of leptin and resistin SNPs with the clinical parameters analyzed. In summary, our results indicate that the A-C haplotype is a predictor of better lipid profile post-surgery and the studied SNPs in ADIPOQ gene are associated to changes in metabolic variables in obese individuals.
Highlights
Obesity is a health problem that affects the welfare of individuals worldwide, and the economy, representing a heavy burden to public health systems (Krzysztoszek et al, 2015)
Our aim was to investigate if single nucleotide polymorphisms (SNPs) located in the 5’ regions of leptin, resistin and adiponectin genes are related to a different profile of weight loss and/or changes in metabolic variables evaluated before and after gastric reduction surgery in obese individuals
Three haplotypes resulting from the combination of the two SNPs in the ADIPOQ gene were observed, G-C, G-G and A-C, with the following frequencies: 0.58, 0.31 and 0.11, respectively
Summary
Obesity is a health problem that affects the welfare of individuals worldwide, and the economy, representing a heavy burden to public health systems (Krzysztoszek et al, 2015). Efficacious and safe pharmacological treatments are still lacking and lifestyle modifications are currently the first choice treatment to the excess of body weight. Surgical interventions are being highly used to treat patients with morbid obesity (body mass index, BMI, equal or over 40 kg/m2). There is a high inter-subject variability among surgical outcomes (Sevilla and Hubal, 2014). Genetic factors have been demonstrated to explain almost 70% of BMI variability (Visscher et al, 2012; Zaitlen et al, 2013). Due to these high estimates of body weight heritability and to inter-individual differences observed in response to bariatric surgery, the role of individual genetic
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call