Abstract
The adipocyte-derived adiponectin hormone bridges obesity and its cardio-metabolic complications. Genetic variants at the ADIPOQ locus, in ADIPOR1, and ADIPOR2 have been associated with adiponectin concentrations and cardio-metabolic complications in diverse ethnicities. However, no studies have examined these associations in Mexican children. We recruited 1 457 Mexican children from Mexico City. Six genetic variants in or near ADIPOQ (rs182052, rs2241766, rs266729, rs822393), ADIPOR1 (rs10920533), and ADIPOR2 (rs11061971) were genotyped. Associations between serum adiponectin, genetic variants, and cardio-metabolic traits were assessed using linear and logistic regressions adjusted for age, sex, and recruitment center. Serum adiponectin concentration was negatively associated with body mass index, waist to hip ratio, low-density lipoprotein cholesterol, total cholesterol, triglycerides, fasting glucose, fasting insulin, homeostatic model assessment of insulin resistance, dyslipidemia and overweight/obesity status (7.76 × 10−40 ≤ p ≤ 3.00 × 10−3). No significant associations between genetic variants in ADIPOQ, ADIPOR1, and ADIPOR2 and serum adiponectin concentration were identified (all p ≥ 0.30). No significant associations between the six genetic variants and cardio-metabolic traits were observed after Bonferroni correction (all p < 6.9 × 10−4). Our study suggests strong associations between circulating adiponectin concentration and cardio-metabolic traits in Mexican children.
Highlights
In 2016, the World Health Organization reported that 1.9 billion adults and 381 million children were overweight/obese, resulting in an important global health concern
We investigated the association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with serum adiponectin concentration under an additive model, adjusted for sex, age, and recruitment center (Table 3)
We assessed the relationship between serum adiponectin concentration and cardio-metabolic traits and the association of 6 SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with adiponectin serum levels and cardio-metabolic traits in Mexican children
Summary
In 2016, the World Health Organization reported that 1.9 billion adults and 381 million children were overweight/obese, resulting in an important global health concern. While serum adiponectin levels negatively correlate with obesity, T2D and the components of the metabolic syndrome in Mexican children, high adiponectin concentrations are associated with a metabolically healthy but obese profile in Mexican adults[27,28,29]. A few studies investigated the association of SNPs in ADIPOQ ADIPOR1, and ADIPOR2 with serum adiponectin levels and cardio-metabolic traits in Mexican and Mexican-American adults[30,31,32,33]. To date, no study has investigated these genetic associations in Mexican children This prompted us to analyze in 1 457 Mexican children 1) the association of adiponectin levels with cardio-metabolic traits, 2) the association of six SNPs in ADIPOQ, ADIPOR1, ADIPOR2, and serum adiponectin levels, and 3) the association of the same SNPs with cardio-metabolic traits
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