Adiponectin and proteinuria in normotensive and hypertensive rats

Camila Morais,Carolina Da Silva,Dora Maria Grassi Kassisse,Filipy Borghi,Priscila Cristina Da Silva

doi:10.20396/revpibic262018282

Abstract

Adiponectin is an anti-inflammatory adipokine produced by adipose tissue and its concentration is depressed in obesity and systemic arterial hypertension. Studies have established a relationship between the adiponectin plasma concentration and complications such as obesity and renal diseases. Proteinuria indicates renal dysfunction or infection and has a negative correlation with adiponectin plasma concentrations. The Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) exhibited higher urinary protein concentrations when compared to Wistar rats (WIS). Therefore, this study aimed to evaluated the serum concentrations of adiponectin and its relation to proteinuria in these rats. The results indicate that WKY present a reduction in the adiponectin serum concentration when compared to WIS and SHR. The low production of adiponectin is related to proteinuria and to the heavy weight of these animals. SHR exhibit similar serum adiponectin levels to WIS, suggesting the hypertension as the responsible factor for the renal dysfunction.

Highlights

Adiponectin is produced by adipose tissue and its serum concentration is reduced in obesity and systemic arterial hypertension
spontaneously hypertensive rats (SHR) and WKY present higher urine protein concentrations when compared to WIS, indicating that proteinuria in SHR may be related to hypertension and in WKY due to the heavy weight and, possibly, the low adiponectin production (6)
The results indicate a significant reduction in adiponectina serum concentrations WKY when compared to WIS and SHR

Summary

Introduction

Adiponectin is produced by adipose tissue and its serum concentration is reduced in obesity and systemic arterial hypertension. Some clinical studies have linked obesity and renal diseases to the adiponectin plasma concentration (1). Adiponectin has an anti-inflammatory and podocyte disruption profile, which has a negative correlation with proteinuria (1).

Objectives

Results

Conclusion