Abstract
SUMMARY 1 In the present study, we examined the possible relationship between circulating adiponectin and plasma levels of nitric oxide (NO) metabolites (nitrite and nitrate) in normotensive and hypertensive men. 2 The concentration of circulating adiponectin was significantly lower in hypertensive men compared with normotensive men. Plasma levels of NO metabolites were also reduced in hypertensive men compared with normotensive men. 3 Circulating adiponectin was significantly correlated with plasma levels of NO metabolites (nitrite and nitrate) in the overall analysis of normotensive and hypertensive men (r = 0.377; n = 52; P < 0.01). When analysis of the correlation for normotensive and hypertensive men was performed separately, there was a significant correlation between circulating adiponectin and plasma levels of NO metabolites in normotensive men, but not in hypertensive men. 4 The results of the present study are consistent with the hypothesis that adiponectin-mediated production of NO may be altered in hypertensive men.
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