Abstract
Background: Plasma adiponectin levels are elevated in patients with chronic systolic heart failure (HF) and associated with adverse outcomes. In contrast, low adiponectin levels are related to endothelial dysfunction in non-HF setting. Herein, we examine the relationship between adiponectin and endothelial dysfunction in systolic HF. Methods: In 139 patients with HF (left ventricular [LV] ejection fraction ≤35%, NYHA functional class II-IV), we measured plasma adiponectin and asymmetric dimetharginine (ADMA, surrogate of endothelial dysfunction) levels and performed comprehensive echocardiography with assessment of cardiac structure and performance.
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