Abstract
AbstractThe kinetics of release of nitroglycerin from adhesive matrix type patches was studied. At a high drug to adhesive ratio the patch consisted of nitroglycerin in part dispersed as droplets in the adhesive and in part dissolved in the adhesive. This patch showed instant release of a major fraction of nitroglycerin in the patch and thereafter release kinetics similar to that which may be expected for a solution system. The rate of skin permeation of nitroglycerin was influenced by the drug to adhesive ratio; first increasing with increase in drug to adhesive ratio and then showing no significant change at a high drug to adhesive ratio at which the system was apparently an emulsion of nitroglycerin in the adhesive.
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