Abstract
Mouse embryonic fibroblasts explore the chemical suitability before spreadingon a given substrate. We find this early phase of cell spreading to becharacterized by transient adhesion patches with a typical mean size of(1.0 ± 0.4) µm and alifetime of (33 ± 12) s. Eventually, these patches fuse to initiate extensive spreading of the cell. We monitor celladhesion using reflection interference contrast and total internal reflection fluorescencemicroscopy. Digital time lapse movies are analysed employing spatio-temporal correlationfunctions of adhesion patterns. Correlation length and time can be scaled to obtain amaster curve at the fusion point.
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