Abstract
Methods Peanut allergy was induced in mice on the C57Bl/6 background (IA) with 4 weekly oral gavage feedings of peanut protein and cholera toxin. After a two-week rest period, sensitized animals were challenged by intraperitoneal injection with crude peanut extract (CPE) and monitored for anaphylaxis. Clinical indicators of peanut allergy include decreased body temperature, scratching, swollen eyes, decreased movement and responsiveness, and moribund condition. We evaluated plasma histamine, total IgE, peanut-specific IgE, and peritoneal albumin levels as in vivo indicators of mast cell degranulation and vascular permeability. Targeted genes and phenotypes
Highlights
From AllerGen NCE Inc.’s Fifth Annual Research Conference: Innovation from Cell to Society Québec City, QC, Canada. 7-9 February 2010
Objective/purpose Adhesion molecules are critical for appropriate localization of leukocytes and induction of adaptive immune responses throughout the body
L-Selectin-/Adhesion molecule required for appropriate localization of naïve lymphocytes to primary lymphoid tissue
Summary
From AllerGen NCE Inc.’s Fifth Annual Research Conference: Innovation from Cell to Society Québec City, QC, Canada. 7-9 February 2010. Objective/purpose Adhesion molecules are critical for appropriate localization of leukocytes and induction of adaptive immune responses throughout the body. Our aim is to better understand the role of cell trafficking and adhesion molecules in an experimental model of peanut allergy.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
