Abstract

ABSTRACTObjective To determine whether laparoscopic surgery causes less adhesion formation than standard laparotomy for uterine horn resection in the rabbit model.Design Experimental prospective animal study: 10 New Zealand female rabbits were randomly allocated to operation by laparoscopy and 10 to standard laparotomy for uterine horn resection.Setting Tertiary referral centre for laparoscopic surgery.Interventions Laparoscopy and laparotomy.Main outcome measures Blauer's adhesions score, fibrous tissue layers and mesothelium layers at the site of the lesion.Results The median Blauer score was 1.0 in the laparoscopy group and 2.5 in the laparotomy group (P = 0.0003). The median number of layers of the area of fibrous tissue was 20 in the animals submitted to laparoscopy, and 65 in those submitted to laparotomy (P < 0.0001). The median number of layers of mesothelium was 1 in the laparoscopy group and 4 in the laparotomy group (P < 0.0001).Conclusion Laparoscopy caused less postoperative adhesion than laparotomy. Rabbits subjected to laparotomy presented a greater degree of mesothelial hyperplasia and more formation of fibrous tissue than the animals subjected to laparoscopy.

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