Adherence to Sulfur Microbial Diet and Ovarian Cancer Survival: Evidence from a Prospective Cohort Study.

Abstract

The study aims to investigate the role of the sulfur microbial diet in the survival of ovarian cancer (OC). A prospective cohort study is conducted with 703 patients diagnosed with OC between 2015 and 2020. Diet informationis collected using a validated food frequency questionnaire. Deathsare ascertained up to March 31, 2021, via the death registry linkage. During the follow-up period (median: 37.2 months, interquartile range: 24.7-50.2 months),130 deaths are observed. A higher sulfur microbial diet scoreis significantly associated with an increased risk of all-cause mortality among OC patients (tertile 3vs tertile 1: HR = 1.93, 95% CI = 1.11-3.35). Each 1-standard deviation increment in the sulfur microbial diet score increases the all-cause mortality risk by 33% (95% CI = 1.04-1.71). Stratified analysis shows that significant associationsare found in OC patients diagnosed over 50 years of age, with body mass index ≥24 kgm-2 , who changed their diet after diagnosis, or without residual lesions. Adherence to the sulfur microbial diet, characterized by high intakes of red meats and processed meats, and low intakes of fruits, vegetables, and whole grains,is associated with poor survival in OC patients.