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Abstract
The massive intestinal secretion seen with cholera and other enterotoxins has been correlated with elevated mucosal adenyl cyclase and cyclic AMP levels. Bowel obstruction is associated with intestinal secretion, and it was of interest to investigate whether this secretion also involved an altered second messenger system. Sixteen rats were obstructed by tying a ligature around the mid-intestine. The bowel proximal to the obstruction showed decreased adenyl cyclase activity by 24 hr and decreased cyclic AMP levels by 48 hr. There was no change in sodium fluoride-stimulated adenyl cyclase activity, indicating normal functioning of the catalytic subunit of the enzyme. Thus, intestinal secretion seen during bowel obstruction is apparently not mediated in the same way as that of cholera, and the decreased adenyl cyclase activity may be ascribed to membrane alterations incurred by bowel distention.
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