Abstract
BackgroundOvarian cancer (OvCA) tissues show abundant expression of the ectonucleotidases CD39 and CD73 which generate immunomodulatory adenosine, thereby inhibiting cytotoxic lymphocytes. Little, however, is known about the effect of adenosine...
Highlights
Ovarian cancer (OvCA) tissues show abundant expression of the ectonucleotidases CD39 and CD73 which generate immunomodulatory adenosine, thereby inhibiting cytotoxic lymphocytes
Expression of CD39 and CD73 in ovarian cancer tissue is associated with poor survival and correlates with transcripts expressed in myeloid cells
Kyoto encyclopedia of genes and genomes (KEGG) pathway analysis using the R2 pathway finder revealed for both CD39 (p = 1.5x10−5) and CD73 (p = 1.6x10−3) a highly significant correlation with antigen processing and presentation. 42 out of 57 genes linked to this pathway show correlation with CD39 (p = 1.5x105)
Summary
Ovarian cancer (OvCA) tissues show abundant expression of the ectonucleotidases CD39 and CD73 which generate immunomodulatory adenosine, thereby inhibiting cytotoxic lymphocytes. Immune function in the tumor microenvironment is shaped by tissue-specific and tumor-derived signals [1] which often decrease the effectiveness of anti-tumor immune responses This is relevant for malignancies like ovarian cancer (OvCA) where immunological processes like infiltration with cytotoxic [2] or regulatory T cells (Treg) [3] heavily affect the prognosis [1, 4, 5]. In this context, we and others have identified tumor-derived adenosine as important immunomodulatory factor [6,7,8,9,10]. OvCA cells, seem to greatly outperform Treg regarding adenosine generation [7]
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