Adenosine to inosine acting on RNA enzymes 1 (ADAR1) contribute to the progression of tumor

Abstract

Tumor occurrence and development is a complicated process. Previous studies confirm that DNA mutations result in activation of downstream pathways of tumor cells. Recently, studies of post-translational modifications showed that RNA editing play an important role in transcriptional mechanism. Thus, RNA editing further enrich the diversity of RNA and protein, participate in the process of many diseases, including cancer. Recently, many studies have focused on the RNA editing enzyme ADAR1 because of the complexity role in tumorigenesis and progression. This article mainly reviewed the role of ADAR1 in the occurrence and development of tumors. Key words: ADAR1; Tumor; RNA editing; A-to-I transition