Abstract
The effects of adenosine A 1 and A 2 agonists on spontaneous central sleep apneas in rats have been examined by simultaneously monitoring sleep and respiration in freely moving unanesthetized animals. Intraperitoneal administration of 1.0 mg/kg of the A 1 receptor agonist R(−) N 6- L-(2-phenylisopropyl)adenosine (L-PIA) and 150 and 300 μg/kg of 2- p-(2-carboxyethyl)phenethylamino-5′- N-ethylcarboxamido-adenosine hydrochloride (CGS 21680), a selective A 2 agonist, decreased the apnea index (AI) during sleep. Within a sleep period, AI increased over time in both control and drug-treated animals. For both agonists, doses effective in reducing AI also significantly reduced sleep efficiency.
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