Abstract
This study investigated sympathetic nerve activity responses in obstructive sleep apnea. Wistar male rats were chronically instrumented for measurements of renal (RSNA) and lumbar (LSNA) sympathetic nerve activity, as well as for an electroencephalogram, electromyogram, and electrocardiogram and systemic arterial pressure, and with a tracheal balloon for induction of apnea. At least 3 days after the surgery, rats were subjected to sleep apnea by inflating the tracheal balloon for 40 seconds during non‐rapid eye movement sleep. RSNA and LSNA increased immediately after the onset of tracheal balloon inflation and by approximately 3 – 4 fold compared with those at pre‐inflation levels. Heart rate decreased in a biphasic manner; it began to fall gradually during the initial several seconds and then it fell abruptly by approximately 200 beats/min. Systemic arterial pressure increased because of the tracheal balloon inflation. We conclude that sympathetic nerve activity plays a critical role in increasing systemic arterial pressure during obstructive sleep apnea in rats. JSPS Grant.
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