Abstract

Uganda has made significant strides in combating HIV/AIDS, yet the concurrent rise in substance abuse presents a complex public health challenge that exacerbates the burden on individuals and healthcare systems. The intersection of substance abuse and HIV/AIDS intensifies health risks and complicates treatment efforts, particularly among vulnerable populations such as youth, sex workers, and men who have sex with men. This review explores the intricate relationship between substance abuse and HIV/AIDS in Uganda, examining the socioeconomic and cultural factors that contribute to this dual epidemic. It also highlights the mental health implications, barriers within the healthcare system, and the critical role of community-based interventions. Furthermore, the review emphasizes the importance of innovative approaches in prevention and treatment, including personalized medicine, pre-exposure prophylaxis (PrEP), medication-assisted therapy (MAT), and the integration of mental health services. The potential of digital health tools, such as telemedicine, is also explored as a means to enhance access to care. Additionally, the review underscores the significance of international organizations and partnerships in supporting local efforts to address these challenges. By integrating these innovative strategies, this review aims to inform policymakers, healthcare practitioners, and community leaders on effective interventions to reduce the prevalence of substance abuse and HIV/AIDS in Uganda and improve health outcomes for affected populations. Keywords: Dual challenges, Substance abuse, HIV/AIDS, Uganda, innovative approaches.

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