Addition of organochromium reagents to aldehydes, ketones and enones: a low-temperature version of the Nozaki–Hiyama reaction

Abstract

Ph2Cr–tetra methylethylenediamine-mediated Nozaki–Hiyama reaction of allylic and propynylic halides leads to rapid 1,2-addition to aldehydes, ketones and enones at –60 °C in moderate to high yields.