Abstract
The prebiotic fiber oligofructose (OFS) may help reduce the negative effects associated with intake of a high‐fat/high sucrose (HFS) diet during pregnancy and lactation. Obesity was induced in female SD rats (n=90) with a HFS diet for 10 wk. Top weight gainers were randomized to 1 of 3 groups for pregnancy and lactation (n=14 per group): 1) HFS; 2) HFS + 10% OFS; 3) Weight matched (WM) to group 2. A 4th lean control (LC) group was kept on standard AIN‐93G diet. Primary outcomes included maternal and offspring body weight (BW) and composition (via DXA). Secondary outcomes included an oral glucose tolerance test, satiety hormone analysis and fecal microbiota profiles. At baseline, obesity induced dams had significantly higher BW (p<0.001) and fasting glucose (p<0.05) than LC. During gestation, BW was lower in LC than all other groups (p=0.001) up to 1 day before due date, then was only lower than the HFS dams; OFS and WM dams were not different than LC. At weaning, HFS dams had higher % body fat than all other groups (p<0.015). Gestational glycemic response was highest in HFS dams (p<0.05). Offspring of HFS dams had higher % body fat than all other groups (p<0.001); offspring of OFS dams were no different then LC or WM pups. Gut microbiota and satiety hormone analysis is ongoing. In conclusion, consumption of OFS during pregnancy and lactation normalizes the high body fat found in HFS‐fed dams and their offspring. Funded by CIHR, AIHS, NSERC.Grant Funding Source: CIHR, NSERC, AIHS
Published Version
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