Abstract
Rats fixed with chronically indwelling electrodes for intracranial stimulation (ICS) of the hypothalamus pressed daily for ICS. Some rats were exposed to ICS of 50, 75, and l00 microA (60-Hz sine waves of .3 sec), while others responded for ICS of 40 microA or less. Exposure to the higher ICS reduced pressing previously sustained by lower ICS. Morphine, amphetamine, and chlorpromazine were tested for their effects on pressing for both groups. Similar drug effects were found for the lower and higher intensity groups.
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