Abstract
Rats were fixed with chronically indwelling electrodes for intracranial stimulation (ICS) of the lateral hypothalamus. Rats pressed daily, in brief sessions, for the ICS. Twenty-five minutes prior to sessions with ICS, rats were given injections of.5 and 1.5 g/kg of ethanol. The smaller dose produced a slight increase in pressing, whereas the larger dose produced a large decrease in pressing. Then one group of rats was made physically dependent on ethanol by force feeding them every few hours across 4 days. The other group was fed only saline. Seven days after the procedure establishing dependence, rats were again tested for effects of ethanol injections on pressing for ICS. After physical dependence, large doses of ethanol did not produce as great a depression in pressing for ICS.
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