Abstract
The V-Akt Murine Thymoma Viral Oncogene Homolog 3 (AKT3) gene is of the serine/threonine-protein kinase family and influences the production of milk fats and cholesterol by acting on the sterol administrative area restricting protein (SREBP). The AKT3 gene is highly preserved in animals, and during lactation in cattle, its expression increases. The AKT3 gene is expressed in the digestive system, mammary gland, and immune cells. A phylogenetic investigation was performed to clarify the evolutionary role of AKT3, by maximum probability. The AKT3 gene sequence data of various mammalian species was evident even with animals undergoing breeding selection. From 39 mammalian species studied, there was a signal of positive diversifying selection with Hominidae at 13Q, 16G, 23R, 24P, 121P, 294K, 327V, 376L, 397K, 445T, and 471F among other codon sites of the AKT3 gene. These sites were codes for amino acids such as arginine, proline, lysine, and leucine indicating major roles for the function of immunological proteins, and in particular, the study highlighted the importance of changes in gene expression of AKT3 on immunity.
Highlights
An evolutionary study provides an understanding of the genetic development occurring across species
The research is concerned with evaluating genetic diversity, understanding the heritability of important traits, reasons for the molecular evolution, and the ability of genes to contribute through breeding selection, biogeography, and genetic drift
Maximum likelihood methods were used to devise the phylogenetic tree within MEGA 6.0 for the Akt Murine Thymoma Viral Oncogene Homolog 3 (AKT3) gene
Summary
An evolutionary study provides an understanding of the genetic development occurring across species. Often a solitary ancestor is responsible for the initiation genetic variation within a population. Speciation, common descent, and natural selection are the main features of evolutionary process. This is understood and explained by various branches of biological sciences including genetics, paleontology, and ecology. Research has become more focused on understanding the evolutionary process of life during the various phases of evolution. The research is concerned with evaluating genetic diversity, understanding the heritability of important traits, reasons for the molecular evolution, and the ability of genes to contribute through breeding selection, biogeography, and genetic drift
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call