Abstract

The basic characteristic of batch bioreactors is their inability to inflow or outflow the substances during the fermentation process. This follows in the simple construction and maintenance, which is the significant advantage of batch bioreactors. Unfortunately, this characteristic also results in the inability of the current industrial and laboratory batch bioreactors to control fermentation production during the process duration. In some recent studies, it was shown that changing the temperature could influence the execution of the fermentation process. The presented paper shows that this phenomenon could be used to develop the closed-loop control system for the fermentation production control in batch bioreactors. First, based on theoretical work, experiments, and numerical methods, the appropriate structure of the mathematical model was determined and parameters were identified. Next, the closed-loop control system structure for batch bioreactor was proposed, and the linear and adaptive control system based on this structure and the derived and identified model were developed. Both modeling and adaptive control system design are new and represent original contributions. As expected, due to the non-linearity of the controlled plant, the adaptive control represents a more successful approach. The simulation and experimental results were used to confirm the applicability of the proposed solution.

Highlights

  • Obtained with the Simple Adaptive Control System

  • A simple adaptive control system based on the model reference adaptive control (MRAC)-ASPR control theory was used for the batch bioreactor’s control implementation

  • The presented results were obtained for the adaptive control system with troller enables that the bioreactor’s dynamics stay the same during repetitions of the batch the reference model represented with the 1st-order term with gain krm = 0.8 and the time processes

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Summary

Introduction

Basic Facts about Fermentation Process and Batch Bioreactors. Fermentation processes are carried out in bioreactors. With regard to the type of fermentation process, bioreactors are divided into three groups: batch bioreactors, fedbatch bioreactors, and continuous bioreactors. The main difference between the individual types of bioreactors is in their ability to supply and discharge substances during the fermentation process. Batch bioreactors are the simplest and do not allow the input and output of substances during the fermentation process. The bioreactor is closed, and we do not have the ability to control the fermentation process. Fedbatch bioreactors allow the introduction of substances during the fermentation process but do not allow the removal of substances. The possibility of adding substances during operation makes it possible to influence the fermentation process in fed-batch bioreactors during operation

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