Abstract
BackgroundThe Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) is the first disease-specific instrument for pulmonary arterial hypertension (PAH) to assess patient-perceived symptoms, activity limitations and quality of life. To be able to use this questionnaire in the Netherlands, the aim of the study was to translate and validate this instrument for the Dutch-speaking population.MethodsFirst the CAMPHOR was translated into Dutch (by means of a bilingual and a lay panel) and field-tested by means of cognitive debriefing interviews with ten PAH patients. For psychometric evaluation, 80 patients with PAH or chronic thromboembolic pulmonary hypertension (CTEPH) were asked to complete the CAMPHOR twice over a two-week period. To test for construct validity, participants also completed the Nottingham Health Profile (NHP).ResultsThe Dutch version of the CAMPHOR showed high internal consistency for all scales (Cronbach’s alpha 0.89–0.91) and excellent reproducibility over two weeks (reliability coefficients 0.87–0.91). Concurrent validity showed that the CAMPHOR scales correlated as expected with the NHP scales. The CAMPHOR was able to distinguish between patient groups based on self-reported general health status, disease severity and NYHA classification demonstrating evidence of known group validity. The CAMPHOR activity limitations scale correlated moderately with the distance walked during the 6‑minute walk test (r = −0.47, p < 0.01) and the symptoms scale with the Borg dyspnoea score (r = 0.51, p < 0.01).ConclusionThe Dutch version of the CAMPHOR is a reliable and valid measure of quality of life and health status in patients with PAH and CTEPH is recommended for use in routine care and in clinical research.
Highlights
Background The Cambridge Pulmonary Hypertension OutcomeReview (CAMPHOR) is the first disease-specific instrument for pulmonary arterial hypertension (PAH) to assess patient-perceived symptoms, activity limitations and quality of life
Pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary vasculature, leading to increased pulmonary vascular resistance resulting in right heart failure and premature death [1]
This paper describes the adaptation and the validation of Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) for Dutch-speaking population in the Netherlands
Summary
Review (CAMPHOR) is the first disease-specific instrument for pulmonary arterial hypertension (PAH) to assess patient-perceived symptoms, activity limitations and quality of life. To be able to use this questionnaire in the Netherlands, the aim of the study was to translate and validate this instrument for the Dutch-speaking population. Pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary vasculature, leading to increased pulmonary vascular resistance resulting in right heart failure and premature death [1]. The aim of therapy is to lengthen survival time, to ameliorate symptoms, to improve quality of life and to reduce the number of hospitalisations [3]. Chronic thromboembolic hypertension (CTEPH) is a form of precapillary PH. Patients with non-operable CTEPH suffer from the same symptoms as patients with
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