Abstract
Purpose: Toll-like receptors are important for activating the innate immune system in response to foreign substances. In addition, it has been proposed that cartilage fragments in the joint may act TLR ligands in the joint, effectively driving inflammation and pain in osteoarthritis. The breakdown of cartilage is mediated by key enzymes: ADAMTS-5 (a disintegrin and metalloproteinase with thrombospondin motifs 5) and MMPs (matrix metalloproteinases). The aim of this study was to investigate the effect of ADAMTS-5 degraded cartilage fragments on tissue turnover in a synovial membrane explant model (SME).
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