Abstract
Purpose: Toll-like receptors are important for activating the innate immune system in response to foreign substances. In addition, it has been proposed that cartilage fragments in the joint may act TLR ligands in the joint, effectively driving inflammation and pain in osteoarthritis. The breakdown of cartilage is mediated by key enzymes: ADAMTS-5 (a disintegrin and metalloproteinase with thrombospondin motifs 5) and MMPs (matrix metalloproteinases). The aim of this study was to investigate the effect of ADAMTS-5 degraded cartilage fragments on tissue turnover in a synovial membrane explant model (SME).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
