Abstract
Hydrogen chloride (HC1) is one of the combustion products formed during the test firing of certain rocket and missile engines. A study was undertaken to determine the LC50 values for rats and mice exposed to various measured concentrations of either HC1 gas or HC1 aerosol for 5 and 30 minutes. This accomplished two objectives; first, to define short-exposure toxicity levels for HC1 in either form and second, to determine whether the aerosol form represented a greater hazard than the gas itself. The respiratory tract was the primary target for HC1 in either form, and lesions were similar to those produced by other severe pulmonary irritants. The results indicate that HC1 gas and HCI aerosol have comparable toxicity in rats and mice. Comparison of these results with another study of HCI gas toxicity in rabbits and guinea pigs showed that HCI gas had the same degree of toxicity in mice, rabbits and guinea pigs while rats were considerably more tolerant.
Published Version
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