Abstract
ConclusionsThe acute toxicity and lethal brain concentration of sodium pentobarbital were determined in newborn rats, young rats of several age groups and adult albino rats. The LD50 of pentobarbital in newborn rats was approximately one-third that of rats 20 days of age and older. Similarly, the lethal concentration of pentobarbital found in the brain tissue of newborn rats was approximately one-third that found in brain tissue of rats 20 days old. Therefore it is concluded that brain tissue of newborn rats per se is more sensitive to depressant effect of pentobarbital than that of adult rats. The incomplete pial-glial barrier of newborn rats does not allow an inordinate sequestration of pentobarbital into brain tissue.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
