Acute Supramaximal Exercise-Induced Adiponectin Increase in Healthy Volunteers: Involvement of Natriuretic Peptides

Abstract

Exercise may modulate lipolysis via leading to natriuretic peptide secretion and beta-adrenergic activation. Adiponectin, an adipose-secreted multifunctional signaling protein, may be the missing link between exercise and lipolytic activity. In this study, we aimed to investigate the effects of supramaximal exercise on plasma levels of adiponectin, atrial natriuretic peptide (ANP), and B-type natriuretic peptide (BNP) in healthy humans. Thirty-one healthy young adult volunteers (male/female, 15/16; mean age±SD, 20.7±1.7 years) underwent a 30-second Wingate anaerobic exercise test on a cycle ergometer and venous blood sampling before and after the exercise test. Plasma ANP and BNP levels were assayed by radioimmunoassay, whereas adiponectin levels were assayed by enzyme-linked immunosorbent assay. Systolic and diastolic blood pressures, heart rate, hematocrit levels and blood lactate were also measured before and after exercise. The mean plasma adiponectin level significantly increased following a 30-second anaerobic exercise test compared to resting level (17.45±4.70 vs 31.29±5.16 μg/mL, respectively, p<0.001). The mean plasma ANP and BNP levels remained comparable before and after the 30-second anaerobic exercise. A 30-sec supramaximal exercise session enhanced circulating adiponectin levels in both gender groups, whereas ANP and BNP levels exerted non-significant alterations. We suggest that acute anaerobic exercise may affect secretory function of adipose tissue which seems not related with natriuretic peptide secretion.