Abstract
Animals are predisposed to infections through varieties of ways which activate the innate immune systems at the initial phase of acute infections. Hemorrhagic Septicemia (HS) is a devastating septicemic disease of cattle and buffaloes caused by a particular serotypes of Pasteurella multocida and serotype B: 2 is the most important cause of the disease in Asia. Therefore, the present study aims to investigate on acute phase protein responses in mice infected with river water contaminated by Pasteurella multocida type B: 2. Five infected mice were placed in each tank containing river water for 24, 48 and 72 h. The groups comprise of five mice each made up of the control, intraperitoneal, oral and the aerosol routes. There were increased concentrations of Haptoglobin (Hp) in the mice inoculated with infected river water kept for 24 h intraperitoneally (p
Highlights
Fastidious serotypes of Pasteurella multocida (Abdullah et al, 2013a), in Asia serotype B: 2 is the Hemorrhagic Septicemia (HS) is a devastating leading cause of HS (Abubakar and Zamri-Saad, 2011)
The present study aims to investigate on acute phase protein responses in mice infected with river water contaminated by Pasteurella multocida type B: 2
The concentration of Serum Amyloid A (SAA) increased significantly (p
Summary
Fastidious serotypes of Pasteurella multocida (Abdullah et al, 2013a), in Asia serotype B: 2 is the Hemorrhagic Septicemia (HS) is a devastating leading cause of HS (Abubakar and Zamri-Saad, 2011). Animals experiencing exogenous or endogenous challenge mount a strong response by activating the innate immune systems at the initial stage of acute infection before the onset of the acquired immune system (Jesse et al, 2013b). The acquired immune system leads to the development of specific cellular and humoral immune responses. During the preliminary challenge the continued existence of the host depends on the capability of the innate reactions to tussle the causes of disease (Eckersall and Bell, 2010)
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