Abstract
The current study was designed to study acute oral toxicity study of polyherbal formulation AV/KPC/10 (M/S Ayurvet Limited, Baddi, India) according to OECD guidelines. For new substances it is the recommended stepwise testing approach for developing scientifically sound data on the safety of the substance. Three wistar rats (2 females and 1 male) were used for the study. AV/KPC/10 in single oral dose (2000mg/kg) supplemented to all rats. The parameters like general appearance, behavior, body weight, mortality and necropsy were studied. No changes in general appearance and mortality was observed. AV/KPC/10 was found to be safe at dose of 2000mg/kg.
Highlights
Traditional and alternative medicine is extensively practiced in the prevention, diagnosis, and treatment of various diseases[1][2]
The acute oral toxicity test aims at establishing the therapeutic index, i.e. defined as the ratio LD50: ED50
The animals for the current study were approved by Institutional Animal Ethical Committee of Bombay Veterinary College, approval no: BVC/IAEC/50/2012
Summary
Traditional and alternative medicine is extensively practiced in the prevention, diagnosis, and treatment of various diseases[1][2]. Despite the widespread use of plants for treatment of several ailments there is a little known about their toxicity and safety. The evaluation of the toxic action of the plant extracts or herbal formulations is important in order to consider them safe before used as medicines[3]. A key stage in ensuring the safety of drugs is to conduct toxicity tests in appropriate animal models[4]. The acute oral toxicity test aims at establishing the therapeutic index, i.e. defined as the ratio LD50: ED50. The term acute oral toxicity is most often used in connection to lethality and lethal dose determinations[5]. The objective of the current experiment was to study the Acute Toxicity of AV/KPC/10 (M/S Ayurvet Limited, India), an herbal formulation containing herbs viz. Phyllanthus niruri, Tephrosia Purpurea, Glycyrrhiza glabra etc. The objective of the current experiment was to study the Acute Toxicity of AV/KPC/10 (M/S Ayurvet Limited, India), an herbal formulation containing herbs viz. Phyllanthus niruri, Tephrosia Purpurea, Glycyrrhiza glabra etc. recommended for the treatment of ketosis in cattle
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