Abstract
Gestational trophoblastic neoplasms comprise a group of interrelated conditions that arise from an abnormal fertilization, and consist of five distinct clinicopathologic entities: complete/partial mole, invasive mole, choriocarcinoma, and placental site trophoblastic tumors. In the United States, hydatidiform moles are observed in approximately 1 in 600 therapeutic abortions and 1 in 1,000–1,200 pregnancies [1]. Rustin and associates conducted a study in the UK analyzing the incidence of secondary malignancies after successful treatment of malignant GTN, and an overall 50 % excess of risk was observed in myeloid leukemia, colon cancer, and breast cancer. Leukemia only developed in those who received etoposide-containing combinations [2].
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