Acute megakaryoblastic leukemia (AML7) about a case

Abstract

Acute myeloid megakaryoblastic leukemia (AML7) is a rare and severe form of acute myeloid leukemia. Its diagnosis is based essentially on cytometric and cytogenetic data, given the complexity of morphological diagnosis. Myelofibrosis and osteolytic lesions may be a particular feature of AML7. Treatment with chemotherapy is considered, but the outcome is often unfavorable. The gold standard of treatment is bone marrow transplantation. Our article reports the case of an infant diagnosed with acute megakaryoblastic leukemia initially revealed by a bone marrow failure syndrome and aggravated by a cerebro-orbital extension with osteolytic lesions of the orbital cavity, treated with chemotherapy with a good clinical-biological evolution.