Abstract
Objective:To describe a novel manifestation of lower motor neuron disease in patients with well-controlled HIV infection.Methods:A retrospective study was performed to identify HIV-positive individuals with acute, painful lower motor neuron diseases.Results:Six patients were identified with HIV and lower motor neuron disease. Two patients met the inclusion criteria of well-controlled, chronic HIV infection and an acute, painful, unilateral lower motor neuron paralytic syndrome affecting the distal portion of the upper limb. These patients had segmental T2-hyperintense lesions in the central gray matter of the cervical spinal cord on MRI. One patient stabilized and the second patient improved with immunomodulatory therapy.Conclusions:This newly described syndrome expands the clinical spectrum of lower motor neuron diseases in HIV.
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