Abstract
Goal. To determine the blood serum level of α2-macroglobulin (α2-MG), α1-antitrypsin (α1-AT), lactoferrin (LF) and albumin in patients with IgE-mediated and IgE-independent atopic dermatitis (AD). Materials and methods. The authors tested blood serum of 60 adult patients suffering from atopic dermatitis at the exacerbation stage (30 patients with IgE-mediated and 30 patients with IgE-independent atopic dermatitis) and 20 healthy donors in order to determine the level of these proteins by rocket immunoelectrophoresis, enzyme-linked immunosorbent assay and immunoturbidimetry methods. Major results. The albumin level is reliably reduced in case of IgE-mediated AD while the LF and α1-AT levels are increased, and concentrations of LF α1-AT and a2-MG are increased as compared to healthy people. There are differences between the level of LF, α2-MG and α1-AT. There was a statistically significant correlation between the LF levels and SCORAD score in both forms, and α2-MG and α1-AT only in case of IgE-independent AD. Conclusion. These results confirm the difference in the roles of these polyfunctional proteins in the pathogenesis of IgE-mediated and IgE-independent AD.
Highlights
The authors tested blood serum of 60 adult patients suffering from atopic dermatitis at the exacerbation stage (30 patients with IgE-mediated and 30 patients with IgE-independent atopic dermatitis) and 20 healthy donors in order to determine the level of these proteins by rocket immunoelectrophoresis, enzyme-linked immunosorbent assay and immunoturbidimetry methods
The albumin level is reliably reduced in case of IgE-mediated atopic dermatitis (AD) while the LF and α1-AT levels are increased, and concentrations of LF α1-AT and α2-MG are increased as compared to healthy people
These results confirm the difference in the roles of these polyfunctional proteins in the pathogenesis of IgEmediated and IgE-independent AD
Summary
При IgЕ-опосредованном АД достоверно снижено содержание альбумина, повышен уровень ЛФ и α1-АТ, а при IgE-независимом АД повышена концентрация ЛФ, α1-АТ и α2-МГ по сравнению с показателями у здоровых доноров. To determine the blood serum level of α2-macroglobulin (α2-MG), α1-antitrypsin (α1-AT), lactoferrin (LF) and albumin in patients with IgE-mediated and IgE-independent atopic dermatitis (AD). Таблицу) установлено, что содержание ЛФ в крови было статистически значимо повышено как при IgE-опосредованном, так и при IgE-независимом АД.
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