Abstract
The aim of this study is to investigate the effectiveness of intravenous administration of Berberis vulgaris root bark aqueous extract (BRBD) on the cardiovascular and renal functions of healthy normotensive rats. The different doses of BRBD 1, 10 and 20 mg/kg were administered intravenously (i.v) in normal rats. Blood pressure, diuretic activity and serum renal profile were analyzed. Intravenous injection of BRBD at the different doses of 1, 10 and 20 mg/kg showed a dose-dependent reduction in mean arterial blood pressure (P<0.001). At different doses of 1, 10 and 20 mg/kg, the hypotensive effect remained for more than one hour. Single dose administration of BRBD at doses of 10 and 20 mg/kg caused a significant increase in urine output (P<0.001) as compared to the control rats. Serum renal profile test (albumin, Urea, Uric Acid, creatinine and BUN) did not show any significant alteration. The authors conclude that the BRBD is a potent hypotensive and possesses diuretic potential
Highlights
Since ancient times, numerous species of plant have been used in folkloric medicine to manage different ailments due to their medicinal properties
Non-significant changes in the serum total protein, albumin, urea, uric acid, creatinine and Blood Urea Nitrogen (BUN) were monitored in the BRBD (10 mg/kg), intravenous treated rats in comparison to their respective control rats
This study assessed the hypotensive and diuretic effects of intravenous injection of aqueous Berberis vulgaris root bark extract on normal rats at the doses of 1, 10 and 20 mg/kg, and arterial blood pressure was recorded through a catheter implanted in the carotid artery
Summary
Numerous species of plant have been used in folkloric medicine to manage different ailments due to their medicinal properties. Research on medicinal plants (for the management of cardiovascular disorders) has become a necessity nowadays Different plants and their extracts reported for their hypotensive activity include Artemisia herba alba (Zeggwagh, Michel, Eddouks, 2014), Tropaeolum majus L (Gasparotto et al, 2011), Berberis orthobotrys Bien Ex Aitch (Alamgeer et al, 2013), Hibiscus sabdariffa L. The observed diuretic activity was associated in several cases with a reduction in arterial blood pressure (Kazama et al, 2012) Taking in consideration these prospects, the present study was planned to observe the Acute Hypotensive and Diuretic Activities of Berberis vulgaris Root Bark Aqueous Extract in Normal Rats
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