Abstract
ABSTRACT Objective To evaluate the effect of Artemisia herba alba (A. herba alba) intravenous injection on cardiovascular and renal function in normal rats. Methods The effect of intravenous injection of A. herba alba extract at the different doses of 50, 100 and 200 mg/kg was investigated in normal rats. Diuresis, heart frequency and electrolytes concentrations were analyzed. Results Intravenous bolus injection of A. herba alba at the different doses of 50, 100 and 200 mg/kg produced a dose dependent reduction in arterial blood pressure ( P A. herba alba injection at the doses of 100 and 200 mg/kg ( P A. herba alba extract at a dose of 200 mg/(kg·h) caused a significant increase in urine output after 4 h of perfusion ( P P P A. herba alba perfusion. Urinary chlorure excretion increased after 2 h of perfusion ( P A. herba alba perfusion ( P Conclusions We conclude that the aqueous A. herba alba extract possesses a potent acute hypotensive effect on normal rats. In addition, A. herba alba perfusion may affect renal function to increase urine and electrolytes excretion.
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