Abstract
The aim of the study was to assess the effect of a single injection of the GnRH agonist decapeptyl on gonadotropin secretion in girls with different pubertal disorders. The test was performed in two groups of girls with premature thelarche (younger and older than 2 years of age), girls with premature adrenarche and postmenarcheal girls with policystic ovaries. The GnRH agonist decapeptyl stimulated gonadotropins secretion in pre- and postmenarcheal girls. The responsiveness of LH was increased significantly in puberty. FSH response was exaggerated in the girls with premature thelarche before the age of 2, but in older premenarcheal girls with the same disorder it was not different than in girls with premature adrenarche. It is concluded that a single dose of the GnRH agonist decapeptyl is a safe and efficacious test for assessment of the function of the pituitary gland in pre-and postmenarcheal girls.
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