Abstract
Acute fatty liver of pregnancy (AFLP) is a rare, potentially fatal disease that occurs late during the third trimester. It is associated with microvesicular fatty infiltration of the liver, hepatic failure, bleeding tendency and encephalopathy. Herein, we report three cases with acute fatty liver of pregnancy including initial presentations, laboratory findings, clinical course and maternal and perinatal outcomes. AFLP should be highly suspected in a pregnant woman that presents with nausea, vomiting, jaundice and epigastric pain during the third trimester. Early diagnosis, prompt delivery and aggressively supportive treatment usually result in a favorable outcome. Genetic screening is recommended in these patients, children and husband.
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