Abstract
At short time intervals (2 and 4 hr) after a single intraperitoneal injection of hydrocortisone (20 mg/rat), gluconeogenesis was studied by intraperitoneal injection in trace amount of one of the following pairs of compounds: DL-lactate-2-14C, DL-lactate-2-3H; DL-malate- 3-14C, DL-malate-2-3H; succinate-2,2′-14C, succinate-2,2′-3H; or glycerol-l,3-14C, glycerol- 2-3H. Conversion of radioactivity to CO2, blood glucose and liver glycogen was measured. With all 14C-labeled substrates there was no marked change of 14CO2 after hydrocortisone. Incorporation of both 14C and 3H from lactate and malate into glucose and glycogen was increased slightly at 2 hr and increased significantly at 4 hr after hydrocortisone. There was no change in incorporation of 14C or 3H from succinate or glycerol. Transfer of 3H from lactate and malate to glucose was somewhat more stimulated than was that of 14C. The observed changes in gluconeogenesis from certain of the labeled substrates are qualitatively similar, but less extensive,...
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